CNQX

SKU: orb1300006

Description

CNQX (FG9065) is a selective competitive antagonist for AMPA and kainate subtypes of ionotropic glutamate receptors, exhibiting IC₅₀ values of 0.3 μM and 1.5 μM, respectively. It is widely used in neuroscience research to study excitatory synaptic transmission, neuronal excitability, and mechanisms of neuroprotection in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 115066-14-3
• MW: 232.1525
• Purity: 99.70% (May vary between batches)
• Formula: C₉H₄N₄O₄
• SMILES: OC1=NC2=C(C=C(C(=C2)C#N)[N+]([O-])=O)N=C1O
• Target: GluR,iGluR
• Solubility: DMSO:20 mg/mL (86.15 mM)

Bioactivity

• Target IC50:
  Kainate:1.5 μM|AMPA:0.3 μM
• In Vitro:
  In rat hippocampal slices bathed in Mg2+-free medium 10 microM CNQX reversibly blocks responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA. The synaptic response evoked by low frequency stimulation of Schaffer collateral-commissural fibres in 1 mM Mg2+-containing medium is completely blocked by this concentration of CNQX. In contrast the synaptic response evoked in Mg2+-free medium is not fully blocked by CNQX.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CNQX, AMPA, non-NMDA, kainate, inhibit, Ionotropic glutamate receptors, FG9065, FG-9065, FG 9065, fear-potentiated, Inhibitor, iGluR, startle

Compound Identifiers

PubChem CID

3721046