Clotrimazole

SKU: orb1310546

Description

Clotrimazole is a broad-spectrum imidazole antifungal agent that functions by inhibiting ergosterol biosynthesis. It is widely used in research to study fungal cell membrane integrity and pathogenesis, with applications in both in vitro assays and in vivo model systems.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23593-75-1
• MW: 344.84
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₁₇ClN₂
• SMILES: Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
• Target: Antifection,Antibiotic,Antibacterial,Antifungal,Autophagy
• Solubility: Ethanol:64 mg/mL (185.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.9 mM);DMSO:36.43 mg/mL (105.64 mM)

Bioactivity

• In Vivo:
  In the CRI-G1 whole-cell of a rat insulinoma cell line, Clotrimazole antagonizes ADP-ribose-activated and single-channel currents. Clotrimazole effectively and rapidly inhibits parasite growth across five different strains of the malignant malaria protozoan. In HEK-293 cells expressing recombinant human TRPM2, Clotrimazole inhibits ADP-ribose-activated currents. At 2 mM concentration, Clotrimazole completely suppresses parasite replication, resulting in the destruction of host cells. Furthermore, Clotrimazole at concentrations ranging from 3 mM to 30 mM entirely inhibits TRPM2-mediated currents.
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• In Vitro:
  Intradermal injection of Clotrimazole in mice stimulates capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, inducing nocifensive behavior and thermal hyperalgesia. In TRPV1 knockout mice, Clotrimazole-induced pain behavior is inhibited by the TRPV1 antagonist BCTC [1,2,3,4-tetrahydro-6-trichloromethyl-pyrimidine-2-one].
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FB 5097, FB5097, FB-5097, Fungal, Antibiotic, Bacterial, Autophagy, BAY b 5097, 14-α Demethylase, Clotrimazole

Compound Identifiers

PubChem CID

2812