Clomipramine hydrochloride

SKU: orb1310788

Description

Clomipramine hydrochloride is a tricyclic antidepressant that acts as a selective serotonin reuptake inhibitor. Following oral absorption and hepatic conversion to desmethylclomipramine, it is used in research models of depression, OCD, and neuropathic pain for in vivo and in vitro pharmacological studies.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 17321-77-6
• MW: 351.31
• Purity: 99.87% (May vary between batches)
• Formula: C₁₉H₂₃ClN₂·HCl
• SMILES: Cl.CN(C)CCCN1c2ccccc2CCc2c1cc(Cl)cc2
• Target: GST,Serotonin Transporter,Dopamine Receptor,5-HT Receptor,Norepinephrine
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.85 mM);H2O:142.32 mM;DMSO:7.5 mg/mL (21.35 mM)

Bioactivity

• Target IC50:
  SERT:0.14 nM(Ki)|Dopamine transporter:3 nM(Ki)|NET:54 nM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DAT, depression, Dopamine Receptor, DopamineReceptor, Clomipramine hydrochloride, Clomipramine Hydrochloride, Clomipramine HCl, Clomipramine, Chlorimipramine, Antidepressant, Anafranil, 5-HT, 5HT Receptor, 5-HTT, 5HTReceptor, 5-hydroxytryptamine, 5-HT reuptake, G34586, G-34586, G 34586, GSTP, Inhibitor, hyperglycemia, NSC 169865, Noradrenaline transporter (Sodium-dependent), inhibit, NSC169865, NSC-169865, obsessive compulsive disorder,OCD, Sert (Sodium-dependent), SERT, Serotonin Transporter, SerotoninTransporter, SLC6A4

Compound Identifiers

PubChem CID

68539