Clobetasol propionate

SKU: orb1225517

Description

Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.(In Vitro):Clobetasol propionate has an IC50 of 15.6 μM for CYP3A4.Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5–/– cells with CYP3A5 overexpression (“3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– cells with CYP3A4 overexpression (“3A5–/– + 3A4OE” cells)).(In Vivo):Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 25122-46-7
• MW: 466.97
• Purity: >98% (HPLC)
• Formula: C₂₅H₃₂ClFO₅
• SMILES: CCC(O[C@]1(C)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C(CCl)=O)=O)=O
• Target: GR
• Solubility: Ethanol: 20 mg/mL (42.82 mM); DMSO: 93 mg/mL (199.15 mM)

Bioactivity

• In Vivo:
  Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.
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• In Vitro:
  Clobetasol propionate has an IC50 of 15.6 μM for CYP3A4.Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5-/- cells with CYP3A5 overexpression (“3A5-/- + 3A5OE” cells), and AsPC-1CYP3A5-/- cells with CYP3A4 overexpression (“3A5-/- + 3A4OE” cells)).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCl-4725 | CGP 9555 | Clobetasol 17-Propionate

Quick Database Links

Gene Symbol

GR