cis-Tadalafil

SKU: orb1705857

Description

cis-Tadalafil (cis-IC-351) is a stereoisomer of tadalafil and a potent inhibitor of phosphodiesterase 5 (PDE5), exhibiting an IC50 of 90 nM. It serves as a valuable research compound for investigating PDE5 function in vascular biology, with applications in studies of pulmonary arterial hypertension using both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 171596-27-3
• MW: 389.404
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₄
• SMILES: CN1CC(=O)N2[C@H](CC3=C(NC4=C3C=CC=C4)[C@H]2C2=CC=C3OCOC3=C2)C1=O
• Target: PDE
• Solubility: DMSO:Soluble

Bioactivity

• Target IC50:
  PDE5:0.09 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Tadalafil (6R ,12aS) diastereomer, (6R ,12aS)-Tadalafil, cis-IC-351, PDE5, Tadalafil (6R ,12aS) diastereomer, Tadalafil EP Impurity A, Tadalafil specified impurity A, Tadalafil, (6R ,12aS), Tadalafil, (6R ,12aS)-

Compound Identifiers

PubChem CID

4687521