Chenodeoxycholic acid

SKU: orb1310239

Description

Chenodeoxycholic acid

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 474-25-9
• MW: 392.57
• Purity: 99.97% (May vary between batches)
• Formula: C₂₄H₄₀O₄
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
• Target: FXR,Endogenous Metabolite,Potassium Channel,Autophagy
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:40 mg/mL (101.89 mM);Ethanol:79 mg/mL (201.24 mM)

Bioactivity

• Target IC50:
  A549 cells:> 200 mM|Caco-2 cells:106 μM|CHO cells:15.6 μM
• In Vitro:
  METHODS: Caco-2 cells were treated with Chenodeoxycholic acid (0.1-1000 μM) for 24 hours, and cell growth inhibition was measured by MTT assay. RESULTS: Chenodeoxycholic acid significantly inhibited Caco-2 cell growth (IC50=106 μM).
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• Cell Research:
  The cell viability is analyzed by incubating transfected HEK-293 cells and CHO cells for 1 h with the corresponding concentration of bile acid and staining with trypan blue. The toxicity of bile acids is analyzed using the tetrazolium salt MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) according to the cell proliferation kit I. No significant differences between control and bile acid-treated cells are obtained in both tests.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PotassiumChannel, Potassium Channel, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, FXR, inhibit, NR1H4, CDCA, Chenodeoxycholic acid, Chenodiol, Bile acid receptor, Autophagy

Compound Identifiers

PubChem CID

21252245