Cefamandole nafate

SKU: orb1221300

Description

Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.(In Vitro):Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.(In Vivo):The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month.After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 42540-40-9
• MW: 512.49
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₇N₆NaO₆S₂
• SMILES: [Na+].Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](OC=O)c1ccccc1)C2=O)C([O-])=O
• Target: Antibacterial
• Solubility: DMSO: ≥ 41 mg/mL (80.00 mM);Water:≥ 29 mg/mL (56.59 mM)

Bioactivity

• In Vivo:
  The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1, 000 mg/kg five days per week for one month. After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.
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• In Vitro:
  Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cephamandole nafate | Cefamandole formate sodium

Quick Database Links

Gene Symbol

Antibacterial