CCG-63802

SKU: orb1308482

Description

CCG-63802 is a reversible, small-molecule inhibitor targeting RGS proteins, specifically disrupting the RGS4-Gα interaction with an IC₅₀ of 1.4 µM. This tool compound is used in vitro to study G protein-coupled receptor (GPCR) signaling pathways and has been applied in research investigating neurological disorders and cardiac function.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 620112-78-9
• MW: 450.512
• Purity: 90.00% (May vary between batches)
• Formula: C₂₆H₁₈N₄O₂S
• SMILES: CC1=CC(OC2=C(\C=C(C#N)\C3=NC4=C(S3)C=CC=C4)C(=O)N3C=CC=C(C)C3=N2)=CC=C1
• Target: GTPase
• Solubility: DMSO:1.67 mg/mL (3.71 mM)

Bioactivity

• Target IC50:
  RGS4:1.4 μM
• In Vitro:
  CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCG63802, CCG-63802, CCG 63802, inhibit, inflammation, Inhibitor, reversible, RGS, RGS Protein, RGS19, RGS4, Regulator of G-protein Signaling, Regulators of G-protein Signaling, selective

Compound Identifiers

PubChem CID

6057678