Carbimazole

SKU: orb1310136

Description

Carbimazole is a prodrug antithyroid agent rapidly metabolized in vivo to its active form, methimazole (MMI). It serves as a critical research tool for investigating hyperthyroidism and Graves' disease mechanisms in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 22232-54-8
• MW: 186.23
• Purity: 99.98% (May vary between batches)
• Formula: C₇H₁₀N₂O₂S
• SMILES: C(OCC)(=O)N1C(=S)N(C)C=C1
• Target: p38 MAPK,Thyroid hormone receptor(THR)
• Solubility: Ethanol:12 mg/mL (64.44 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.74 mM);DMSO:60 mg/mL (322.18 mM)

Bioactivity

• In Vivo:
  Once absorbed by the human body, Carbimazole is metabolized into Methimazole, which exerts anti-thyroid activity. It specifically targets conditions such as hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (thyroid inflammation).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antithyroid agent, Athyromazole, Carbimazol, Carbimazole, methimazole, MMI, Neomercazole, inhibit, Inhibitor, Graves' disease, THR, Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid hormone receptor, Thyroid hormone receptor(THR), Thyroid peroxidase

Compound Identifiers

PubChem CID

31072