Bunaftide

SKU: orb1710192

Description

Bunaftide is an antiarrhythmic agent known to suppress ventricular tachycardia induced by aconitine. It is utilized in cardiovascular research, particularly in studies investigating cardiac electrophysiology, and has been applied in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 32421-46-8
• MW: 326.48
• Purity: 99.16% (May vary between batches)
• Formula: C₂₁H₃₀N₂O
• SMILES: C(N(CCN(CC)CC)CCCC)(=O)C=1C2=C(C=CC1)C=CC=C2
• Target: Others
• Solubility: DMSO:60 mg/mL (183.78 mM)

Bioactivity

• In Vitro:
  Bunaftide (0.5-2.0 mM) causes contraction and rounding of the cells with loss of microvilli-like processes. 0.4 mM Bunaftide increases and 0.8-1.0 mM markedly decreases the percentage of mitotic cells, without accumulation of cells in any particular stage of mitosis. Bunaftide (1, 5, and 10 mg/L) produces a concentration-dependent depression of the maximum rate of rising of the action potential in guinea pig papillary muscle preparations without affecting the resting membrane potential and the action potential amplitude. The action potential duration (APD50, APD90) is significantly prolonged by the treatment with 1 and 5 mg/L Bunaftide, while it is not changed by the treatment with 10 mg/L.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Meregon, Bunaftide, Bunaftine, Bunaphtide

Compound Identifiers

PubChem CID

36131