BRD7552

SKU: orb1300460

Description

BRD7552

Research Area

Signal Transduction

Key Properties

• CAS Number: 1137359-47-7
• MW: 711.63
• Purity: >99.99% (May vary between batches)
• Formula: C₃₃H₃₃N₃O₁₅
• SMILES: CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@](O)([C@H]2OC(=O)Nc2ccc3OCOc3c2)C(=O)Nc2ccc3OCOc3c2)cc1
• Target: IGF-1R,Others
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:93 mg/mL (130.69 mM);Ethanol:93 mg/mL (130.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.64 mM)

Bioactivity

• In Vitro:
  BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, BRD 7552, changes, BRD7552, BRD-7552, ductal, epigenetic, human, Inhibitor, insulin, inhibit, islets, primary, PDX1, promoter

Compound Identifiers

PubChem CID

91895231