BRD-73954

SKU: orb1226274

Description

The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM; show no significant inhibition for other HDAC isoforms (IC50>9 uM); robustly increase in α-tubulin acetylation, has no change in the acetylation state of H3 in Hela cells.

Key Properties

• CAS Number: 1440209-96-0
• MW: 284.3098
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₆N₂O₃
• SMILES: C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO
• Target: HDAC
• Solubility: DMSO: ≥ 35 mg/mL

Bioactivity

• In Vitro:
  BRD73954 (10 μM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western blot analysis. Cell line: HeLa cells. Concentration: 10 μM. Incubation time: 48 hours. Result: Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD73954

Quick Database Links

Gene Symbol

HDAC