BP 897 hydrochloride

SKU: orb1308528

Description

BP 897 is a potent and selective dopamine D3 receptor agonist (Ki = 0.92 nM) with weak D2 receptor antagonism (Ki = 61 nM). It shows low affinity for D1 and D4 receptors. This profile makes it a valuable research tool for investigating D3 receptor function in neuropsychiatric disorders, including addiction and schizophrenia, in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 314776-92-6
• MW: 454
• Purity: 99.42% (May vary between batches)
• Formula: C₂₆H₃₂ClN₃O₂
• SMILES: Cl.COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1
• Target: Dopamine Receptor
• Solubility: DMSO:9 mg/mL (19.82 mM)

Bioactivity

• Target IC50:
  D3:(ki)0.92 nM|D2:61 nM(ki)|D1:3 μM|D4:0.3 μM(ki)
• In Vivo:
  BP 897 (0, 0.05, 0.5, 1 mg/kg) inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects. BP 897 binds to D2-receptor in mouse striatum with an ED50 of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg.
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• In Vitro:
  BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1.0 ± 0.3 nM, and increases mitogenesis, another D3-receptor-mediated response (EC50 = 3 ± 1 nM) in NG 108-15 cells expressing the human D3 receptor. However, BP 897 (1 μM) does not inhibit cyclic AMP accumulation or trigger mitogenesis in cells expressing the D2 receptor. With a 70 times lower affinity at the D2 receptor (Ki, 61 nM). BP 897 also weakly binds to α1 and α2 adrenergic receptors (Ki = 60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki = 84 and 345 nM, respectively), and has negligible affinities (Ki > 1 μM) at muscarinic, histamine and opiate receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

motivational, inhibit, Inhibitor, DopamineReceptor, Dopamine Receptor, Dopamine, D1 receptor, D1, D2 receptor, D2, D4 receptor, D4, D3 receptor, D3, cocaine drug-seeking, addiction, behaviour, BP 897, BP 897 hydrochloride, BP 897 Hydrochloride, BP897, BP-897, BP897 Hydrochloride, BP-897 Hydrochloride, stimuli, rewarding

Compound Identifiers

PubChem CID

3038494