Basimglurant sulfate

SKU: orb3211334

Description

Basimglurant (RG7090; RO4917523) sulfate is a selective, orally bioavailable negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5) that can cross the blood-brain barrier. It exhibits a Ki of 1.4 nM for [³H]-ABP688 and 35.6 nM for [³H]-MPEP. Basimglurant sulfate inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, modulates nucleus accumbens dopamine levels, and exerts anxiolytic, antidepressant-like, analgesic, and wakefulness-promoting effects, while altering δ-wave power during non-rapid eye movement sleep. It is applicable in research related to depression, fragile X syndrome, and anxiety disorders.

Key Properties

• CAS Number: 1034442-21-1
• MW: 423.85
• Formula: C₁₈H₁₅ClFN₃O₄S
• SMILES: O=S(=O)(O)O.FC1=CC=C(C=C1)N2C(=NC(C#CC=3C=CN=C(Cl)C3)=C2C)C
• Target: GluR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GluR