BAN ORL 24 dihydrochloride

SKU: orb1710328

Description

BAN ORL 24 is a potent and selective antagonist of the nociceptin/orphanin FQ (NOP) receptor. It is a valuable research tool for investigating the N/OFQ system's role in neurological disorders, supporting both in vitro binding assays and in vivo behavioral studies.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1401463-54-4
• MW: 506.51
• Purity: 95.03% (May vary between batches)
• Formula: C₂₇H₃₇Cl₂N₃O₂
• SMILES: O=C([C@@H]1N(CCC1)CC2=CC=CC=C2)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl
• Target: Opioid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.87 mM);DMSO:180 mg/mL (355.37 mM);H2O:80 mg/mL (157.94 mM)

Bioactivity

• Target IC50:
  NOP receptor:50 μM|μ opioid receptor:0.224 μM
• In Vivo:
  BAN ORL 24 (10 mg/kg; i.v.) attenuated the duration of the thermal nociceptive antisensitization effect of BPRIM97 and inhibited BPRIM97-induced antinociceptive sensitization at 90 min postinjection. In tail-clip testing, BAN ORL 24 did not attenuate BPR1M97-induced antinociceptive sensitization at 30 min postinjection.
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• In Vitro:
  BAN ORL 24 has antagonist for NOR (IC50=50 μM) and MOR (opioid receptor subtype) (IC50=0.224 μM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAN ORL 24, Opioid Receptor, OpioidReceptor

Compound Identifiers

PubChem CID

56840444