BAM15

SKU: orb1308585

Description

BAM 15

Research Area

Cell Biology, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 210302-17-3
• MW: 340.3
• Purity: >98%
• Formula: C₁₆H₁₀F₂N₆O
• SMILES: FC1=C(NC2=NC3=NON=C3N=C2NC2=C(F)C=CC=C2)C=CC=C1
• Target: Mitochondrial Metabolism,OXPHOS
• Solubility: Soluble in DMSO (up to at least 35 mg/ml)

Bioactivity

• In Vivo:
  Animals that receive BAM 15 are protected from kidney injury compared to vehicle-treated mice, such as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration.
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• In Vitro:
  BAM 15 effectively enhances mitochondrial respiration and oxygen consumption across a wide concentration range without increasing reactive oxygen species (ROS), displaying a broader range of action compared to FCCP in myoblasts and hepatocytes. Despite structural differences from FCCP, BAM 15 at concentrations between 100 nM and 1 μM increases the cellular oxygen consumption rate (OCR) similarly to FCCP, but at higher concentrations (1 μM to 50 μM), it sustains uncoupled respiration more effectively across various cell lines. Additionally, BAM 15 causes mitochondrial swelling, indicating its role as a protonophore, and demonstrates greater cell viability than FCCP when used up to 50 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAM15, BAM-15, BAM 15, Inhibitor, inhibit, Mitochondrial Metabolism, MitochondrialMetabolism, oxidative phosphorylation (OXPHOS)

Compound Identifiers

PubChem CID

565708