Azimilide Dihydrochloride

SKU: orb1299760

Description

Azimilide Dihydrochloride is a class III antiarrhythmic compound that inhibits both the slow (IKs) and rapid (IKr) delayed rectifier potassium channels. It is utilized in cardiovascular research to study arrhythmia mechanisms and has been investigated in both in vitro assays and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 149888-94-8
• MW: 530.88
• Purity: 98.83% (May vary between batches)
• Formula: C₂₃H₃₀Cl₃N₅O₃
• SMILES: Cl.Cl.CN1CCN(CCCCN2C(=O)CN(\N=C\c3ccc(o3)-c3ccc(Cl)cc3)C2=O)CC1
• Target: Potassium Channel
• Solubility: DMSO:1.33 mg/mL (2.51 mM)

Bioactivity

• In Vivo:
  Azimilide has shown excellent efficacy (>85%) in suppressing supraventricular arrhythmias in a variety of dog models. It also suppressed complex ventricular arrhythmias in infarcted dogs and, in a sudden death cardiac model, decreased mortality.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azimilide, Azimilide Dihydrochloride, inhibit, KcsA, Inhibitor, NE 10064, NE 10064 Dihydrochloride, NE10064, NE-10064, NE10064 Dihydrochloride, NE-10064 Dihydrochloride, PotassiumChannel, Potassium Channel

Compound Identifiers

PubChem CID

9571003