Azide-PEG12-Tos

SKU: orb1307550

Description

Azide-PEG12-Tos is a heterobifunctional PROTAC linker featuring an azide group and a tosylate terminus, connected by a polyethylene glycol (PEG12) spacer. This water-soluble linker is widely used in chemical biology for constructing proteolysis-targeting chimeras (PROTACs) for both in vitro and in vivo degradation studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1821464-56-5
• MW: 725.85
• Purity: 98.72% (May vary between batches)
• Formula: C₃₁H₅₅N₃O₁₄S
• SMILES: S(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])(=O)(=O)C1=CC=C(C)C=C1
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs are molecules consisting of two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PEGs, PROTAC Linker, PROTAC Linkers, PROTACLinker, inhibit, Inhibitor, Azide PEG12 Tos, AzidePEG12Tos, Azide-PEG-12-Tos, Azide-PEG12-Tos

Compound Identifiers

PubChem CID

119058275