AVS Bio - llama anti-human P-Selectin

SKU: PODI-P001

Description

Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is a member of the Selectin family. It is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelet3 or Weibel-Palade bodies of endothelial cells, in response to a variety of inflammatory and thrombogenic stimuli. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL-1 (P-Selectin glycoprotein ligand-1), and thereby mediates the adhesion of leukocytes to platelets and the endothelium. Additionally, the P-selectin/PSGL-1 interaction induces platelet activation thereby enhancing platelet aggregation and thrombus formation.

Images & Validation

• Tested Applications: ELISA, FC
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Isotype: VHH
• Clone No.: B10.6
• Immunogen: Purified recombinant human P-selectin
• Target: Human P-Selectin
• Purification: IMAC purified with Nickel excel Sepharose, >98%
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: PBS
• Concentration: 3.73 mg/ml
• Expiration Date: For shelf life and expiration details, please refer to the Certificate of Analysis (CoA).
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Human P-Selectin