AVS Bio - Human PAD2

SKU: MQ16.201

Description

PAD2 (Peptidylarginine Deiminase 2) is an enzyme expressed in a wide range of tissues, including immune cells such as macrophages and neutrophils. It catalyzes the citrullination (deimination) of arginine residues in proteins, a post-translational modification that can alter protein structure and function. Dysregulated PAD2 activity has been associated with autoimmune and neurodegenerative diseases, including rheumatoid arthritis, multiple sclerosis, and certain cancers, where aberrant citrullination contributes to inflammation and autoantigen formation.

Images & Validation

• Application Notes:
  Recombinant human PAD2 is intended for studies on its deimination properties.

Key Properties

• Biological Activity: Activity has been tested in an MQR Antibody Based Assay for PAD activity (ABAP) (Cat. no. MQ17.101) and compared to rabbit skeletal muscle PAD from Sigma-Aldrich (Figure 1).
• Purification: Recombinant human PAD2 includes a HIS-tag and has been purified from bacterial cell lysate using Ni 2+-beads.

Storage & Handling

• Storage: Store at - 80°C. *AVOID FREEZE-THAW CYCLES*
• Form/Appearance: solution
• Buffer/Preservatives: Solution in 20mM Tris-HCl, pH 7.6, containing 10mM β mercaptoethanol, 400mM NaCl, 250mM Imidazole, 1mM EDTA and 10% glycerol.
• Expiration Date: For shelf life and expiration details, please refer to the Certificate of Analysis (CoA).
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only