AVS Bio - Monoclonal Human anti-seryl-tRNA synthetase Immunoglobulin

SKU: MQR2.3901

Description

Antibody against anti-seryl-tRNA synthetase, which catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.

Images & Validation

• Tested Applications: ELISA, IP
• Dilution Range: ELISA: 1:1000 –1:5000 IP: 2 µg/ml Other applications: since applications vary, optimum working dilution of the product should be determined in the appropriate assay. Unless the stability in the actual test system has been established, it is recommended to dilute the product immediately before use.
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Isotype: Human IgG1, κ
• Immunogen: Seryl-tRNA-synthetase. Domain: V2-A514 of514.
• Target: seryl-tRNA synthetase (SRSA)
• Purification: Protein A purified.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: solution
• Buffer/Preservatives: The antibody is supplied in PBS.
• Expiration Date: For shelf life and expiration details, please refer to the Certificate of Analysis (CoA).
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

seryl-tRNA synthetase (SRSA)