Anti-osteoporosis agent-12

SKU: orb3173563

Description

Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative that exhibits strong anti-osteoporotic properties. It powerfully inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC50 of 7.96 nM. Additionally, Anti-osteoporosis agent-12 dose-dependently improves key micro-CT parameters of bone, reduces serum bone resorption marker levels (CTx), and effectively prevents bone loss induced by ovariectomy. This agent is useful for osteoporosis research.

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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