Anisodamine

SKU: orb1705028

Description

Anisodamine is a muscarinic and nicotinic cholinoceptor antagonist with affinity comparable to atropine. It is utilized in research on microcirculatory dysfunction, shock, and organophosphate poisoning, with applications in both in vivo and in vitro experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 55869-99-3
• MW: 305.37
• Purity: 99.88% (May vary between batches)
• Formula: C₁₇H₂₃NO₄
• SMILES: CN1[C@@H]2C[C@H](O)[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c1ccccc1
• Target: AChR
• Solubility: DMSO:90 mg/mL (294.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.81 mM);H2O:18 mg/mL (58.94 mM)

Bioactivity

• In Vivo:
  Intraperitoneal administration of Anisodamine (50 mg/kg) significantly reduces mortality of LPS-induced shock mice(20%).
• In Vitro:
  In RAW264.7 cells, Anisodamine (100 μg/mL) blocks muscarinic receptors thus allowing more endogenous ACh binding to the α-7nAChR and attenuating α-bungarotoxin binding.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

muscarinic receptor, Nicotinic Receptor, 6-β-Hydroxyhyoscyamine, 6-b-Hydroxyhyoscyamine, 6-beta-Hydroxyhyoscyamine, 6-Hydroxyhyoscyamine, AChR, Anisodamine

Compound Identifiers

PubChem CID

6918612