Amoxicillin

SKU: orb1310072

Description

Amoxicillin Anhydrous is a broad-spectrum aminopenicillin antibiotic that exerts bactericidal effects by inactivating penicillin-binding proteins (PBPs), thereby inhibiting bacterial cell wall synthesis and leading to cell lysis. It is widely used in research applications, including in vitro susceptibility testing and in vivo models of bacterial infection.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 26787-78-0
• MW: 365.4
• Purity: 99.92% (May vary between batches)
• Formula: C₁₆H₁₉N₃O₅S
• SMILES: [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O
• Target: Antibacterial,Antibiotic
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:250 mg/mL (684.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.47 mM)

Bioactivity

• In Vivo:
  Amoxicillin was released more rapidly from phosphate buffer solution at pH 7.8 than from hydrochloric acid at pH 1.0. Amoxicillin was degraded in hydrochloric acid solution at 37°C, pH 1.0, indicating that Amoxicillin is less stable in acidic environment.Amoxicillin (≤8 mg/ml) inhibited 4 out of 15 strains.Amoxicillin (4 mg/ml) in combination with clavulanic acid (≤2 mg/ml) Amoxicillin (4 mg/ml) in combination with clavulanic acid (≤2 mg/ml) inhibited 14 out of 15 strains. In combination with cefotaxime (4 mg/ml), the IC50 of Amoxicillin on the strains was reduced from 0.5 mg/ml to 0.06 mg/ml, ranging from 0.01 to 0.25 mg/ml.Amoxicillin-treated cells secreted large amounts of IL-5, with little or no secretion of IL-4, TNFα, and interferon-gamma. Amoxicillin-specific T-cell clones did not exhibit drug-specific cytotoxicity, but were present to kill target cells at concanavalin A, suggesting that its primary capacity is cytolysis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell wall, Bacterial, antimicrobial, antibiotic, Antibiotic, Amoxycillin, Amoxicillin, Inhibitor, inhibit, polypeptides

Compound Identifiers

PubChem CID

33613