Amodiaquine

SKU: orb1298982

Description

Amodiaquine is a synthetic aminoquinoline antimalarial agent. It is widely used in research to study malaria treatment mechanisms and drug resistance, both in vitro against Plasmodium cultures and in vivo within animal models of infection.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 86-42-0
• MW: 355.861
• Purity: 99.99% (May vary between batches)
• Formula: C₂₀H₂₂ClN₃O
• SMILES: CC[NH+](CC)CC1=C([O-])C=CC(NC2=CC=NC3=C2C=CC(Cl)=C3)=C1
• Target: Parasite,NR4A,Histone Methyltransferase
• Solubility: DMSO:71 mg/mL (199.52 mM);Methanol:50 mg/mL (140.5 mM)

Bioactivity

• Target IC50:
  Nurr1-LBD (ligand binding domain):20 μM (EC50)
• In Vitro:
  Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH). a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH. Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. These results suggest that Nurr1 serves a novel target for ICH therapy.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCL2, CCL2, anti-inflammatory, antimalarial, Amodiaquin, Amodiaquine, Inhibitor, Histone Methyltransferase, HistoneMethyltransferase, IL-1β, Parasite, N-methyltransferase, Nurr1, neuroprotective, inhibit

Compound Identifiers

PubChem CID

2165