A-259745

SKU: orb3173662

Description

A-259745 is an orally active antimitotic agent that binds to the colchicine site on tubulin. It exhibits potent in vitro cytotoxic activity against both multidrug-resistant and non-multidrug-resistant cancer cell lines, with ED50 values of 0.018 μM for HCT-15 and 0.028 μM for NCI-H460 cells. A-259745 inhibits tubulin polymerization, disrupting the dynamic equilibrium of the mitotic spindle, causing dividing cells to arrest in the metaphase-anaphase transition, which subsequently induces apoptosis (apoptosis). In mouse tumor models, A-259745 demonstrates dose-dependent antitumor efficacy and is useful for cancer research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 256934-83-5
• MW: 366.42
• Formula: C₂₁H₂₂N₂O₄
• SMILES: N1=C(OC(C2=CC(OC)=C(OC)C(OC)=C2)C1)C=3C=CC4=C(C=CN4C)C3
• Target: Microtubule Associated,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule Associated,Apoptosis