7-Methoxyrosmanol

SKU: orb1297478

Description

7-Methoxyrosmanol

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 113085-62-4
• MW: 360.44
• Purity: 98.40% (May vary between batches)
• Formula: C₂₁H₂₈O₅
• SMILES: [H][C@@]12[C@@H]3OC(=O)[C@@]1(CCCC2(C)C)c1c(O)c(O)c(cc1[C@@H]3OC)C(C)C
• Target: cAMP,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM);DMSO:12 mg/mL (33.29 mM)

Bioactivity

• In Vitro:
  In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid and carnosol) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol and semisynthetic derivatives (7-Methoxyrosmanol 7-O-ethylrosmanol, and 11,12-O,O-dimethylcarnosol) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml). The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, cAMP, 7 Methoxyrosmanol, 7-O-Methylrosmanol, 7Methoxyrosmanol, 7-Methoxyrosmanol

Compound Identifiers

PubChem CID

23243692