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7-Hydroxyaristolochic acid A

SKU: orb1684989

Description

7-Hydroxyaristolochic acid A is a nephrotoxic and carcinogenic derivative of aristolochic acid. It induces apoptosis in renal NRK-52E cells via COX-2/PGE2 and inhibits the APE1/Nrf2/HO-1 antioxidant pathway, making it a tool for studying nephrotoxicity mechanisms in vitro.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number79185-75-4
MW357.27
Purity99.47% (May vary between batches)
FormulaC17H11NO8
SMILESO=C(C1=CC2=C(C3=C4C=CC(O)=C(C4=CC([N+]([O-])=O)=C13)OC)OCO2)O
TargetDNA/RNA Synthesis
SolubilityDMSO:80 mg/mL (223.92 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

7 Hydroxyaristolochic acid A, 7Hydroxyaristolochic acid A, 7-Hydroxyaristolochic acid A

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Key Properties

No computed properties available.

Protocol Information

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1 mg
$ 540.00
5 mg
$ 1,320.00
10 mg
$ 1,840.00
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