6-Phosphogluconic acid

SKU: orb1940837

Description

6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI).The activity of phosphoglucose isomerase was inhibited intensely and competitively by 6-Phosphogluconic acid, with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate.(In Vitro):With glucose 6-phosphate as the substrate, at concentrations from 0.05 to 0.5 mM, the activity of the enzyme was inhibited completely in the presence of 0.5-2.0 mM 6-Phosphogluconic acid. With 0.05-0.2 mM fructose 6-phosphate as the substrate, it was inhibited greater than or equal to 85% at the same concentrations of the inhibitor. No significant changes were observed in the values of Km, Vmax, and Ki for phosphoglucose isomerase in the brain of 6-aminonicotinamide-treated rats.

Key Properties

• CAS Number: 921-62-0
• MW: 276.134
• Purity: >98% (HPLC)
• Formula: C₆H₁₃O₁₀P
• SMILES: O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

Bioactivity

• In Vitro:
  6-Phosphogluconic acid (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only