6-Mercaptopurine

SKU: orb1306123

Description

6-Mercaptopurine monohydrate is a nucleoside metabolic inhibitor that disrupts purine synthesis, thereby impeding nucleic acid production. It is widely used in leukemia research, both in vitro and in vivo, for studying remission maintenance and combination therapies.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 6112-76-1
• MW: 170.2
• Purity: >98%
• Formula: C₅H₄N₄S·H₂O
• SMILES: c1nc2c([nH]1)c(=S)nc[nH]2.O
• Target: GTPase
• Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml with warming)

Bioactivity

• In Vitro:
  Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6-MP

Compound Identifiers

PubChem CID

2724350