5-Methoxyindole-3-acetic acid

SKU: orb1308879

Description

5-Methoxyindole-3-acetic acid (5-MIAA) is a primary metabolite of melatonin, commonly isolated from pineal tissue. It serves as a key biomarker in research investigating melatonin metabolism, circadian rhythm disorders, and neuroendocrine studies in both in vivo and in vitro experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3471-31-6
• MW: 205.2099
• Purity: 98.55% (May vary between batches)
• Formula: C₁₁H₁₁NO₃
• SMILES: COC1=CC2=C(NC=C2CC(O)=O)C=C1
• Target: Endogenous Metabolite
• Solubility: DMSO:88 mg/mL (428.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (16.08 mM)

Bioactivity

• In Vivo:
  Transplacental administration of 5-methoxyindole-3-acetic acid possessing blastomogenic activity induced the development of malignant and benign neoplasms (lymphosarcomas, adenomas, hepatomas and other tumours) in 84% of C57BL/6 mouse progeny. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were more malignant.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5 Methoxyindole 3 acetic acid, 5-Methoxyindoleacetic acid, 5Methoxyindole3acetic acid, 5-Methoxyindole-3-acetic acid, Inhibitor, inhibit, Methoxyindoleacetic acid, EndogenousMetabolite, Endogenous Metabolite, Human Endogenous Metabolite

Compound Identifiers

PubChem CID

18986