4-P-PDOT

SKU: orb1707750

Description

4-P-PDOT

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 134865-74-0
• MW: 279.38
• Purity: 99.91% (May vary between batches)
• Formula: C₁₉H₂₁NO
• SMILES: CCC(=O)N[C@H]1C[C@@H](c2ccccc2)c2ccccc2C1
• Target: Melatonin Receptor,MT Receptor
• Solubility: DMSO:41.67 mg/mL (149.15 mM)

Bioactivity

• In Vivo:
  4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice.
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• In Vitro:
  In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

oxidative, inhibit, Nrf2, MTReceptor, MT Receptor, MT2, MT2 receptor, GSSG, GSH, ERK, memory, Melatonin Receptor, MelatoninReceptor, Melatonin, Inhibitor, damage, 4PPDOT, 4-P-PDOT, 4-phenyl-2- propionamidotetralin, 4 P PDOT

Compound Identifiers

PubChem CID

24750357