4-Methylpyrazole

SKU: orb1224063

Description

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.\n(In Vivo):Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice.

Key Properties

• CAS Number: 7554-65-6
• MW: 82.1
• Purity: >98% (HPLC)
• Formula: C₄H₆N₂
• SMILES: CC1=CNN=C1
• Target: AChR
• Solubility: Water: 146 mg/mL

Bioactivity

• In Vivo:
  Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice. Animal model: Male CD-1 mice weighing 18-25 g. Dosage: 25 mg/kg. Administration: IP; single dose. Result: Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Methylpyrazole

Quick Database Links

Gene Symbol

AChR