4-Methylamino antipyrine

SKU: orb1310046

Description

4-Methylamino antipyrine is the primary active metabolite of the non-steroidal anti-inflammatory drug (NSAID) Metamizole, a COX inhibitor. This metabolite exhibits analgesic and antipyretic properties with weaker anti-inflammatory effects, making it a relevant compound for pharmacological research in both in vitro enzyme studies and in vivo pain models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 519-98-2
• MW: 217.267
• Purity: 99.87% (May vary between batches)
• Formula: C₁₂H₁₅N₃O
• SMILES: CNC1=C(C)N(C)N(C1=O)C1=CC=CC=C1
• Target: COX,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.6 mM);DMSO:2.78 mg/mL (12.8 mM)

Bioactivity

• In Vivo:
  Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine .
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• In Vitro:
  At room temperature and in an atmosphere with oxygen, Metamizole is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, nonopioid, NSAID, metabolite, Metamizole, Inhibitor, 4Methylamino antipyrine, 4-Methylamino antipyrine, 4 Methylamino antipyrine, analgesic, anti-inflammatory, antipyretic, Drug Metabolite, DrugMetabolite, Cyclooxygenase, COX

Compound Identifiers

PubChem CID

10618