2-methoxycinnamaldehyde

SKU: orb1299808

Description

2-Methoxycinnamaldehyde is a bioactive constituent of Cinnamomum cassia with documented antitumor properties. It is widely utilized in cancer research, demonstrating activity in both in vitro cell culture studies and in vivo animal models to investigate mechanisms of apoptosis and proliferation inhibition.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1504-74-1
• MW: 162.1852
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀H₁₀O₂
• SMILES: COC1=C(\C=C\C=O)C=CC=C1
• Target: Mitochondrial Metabolism,Topoisomerase,Caspase,Apoptosis,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.33 mM);DMSO:60 mg/mL (369.94 mM)

Bioactivity

• In Vitro:
  2-methoxycinnamaldehyde(2-MCA) inhibited cell proliferation in SK-Hep-1 cells in a dose- and time-dependent manner. The inhibitory concentration (IC50) value following 48 hours of incubation was 25.72 μM.
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• Cell Research:
  Cells were seeded in 96-well culture plates (1×10^4 cells/well). After incubated for 24 hours, the cells were treated with different concentrations of 2-MCA for 24 hours, 48 hours, and 72 hours. The cell viability was determined by Cell Proliferation Kit II (XTT) following the manufacturer's protocol. The absorbance was measured using Tecan infinite M200 spectrophotometer at 492 nm with a reference wavelength of 650 nm.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, O-methoxycinnamaldehyde, Inhibitor, 2methoxycinnamaldehyde, 2-methoxycinnamaldehyde, 2-Methoxycinnamaldehyde, 2 methoxycinnamaldehyde, Apoptosis

Compound Identifiers

PubChem CID

15173