0990CL

SKU: orb1707764

Description

0990CL is a specific inhibitor of heterotrimeric Gαi subunits, binding to GDP-bound Gα to disrupt α2AR-mediated cAMP signaling. In cellular models, it partially restores cAMP at low doses, while higher concentrations (e.g., 10µM) can impact cell viability. This tool compound is valuable for in vitro studies investigating GPCR and cAMP pathways in signal transduction research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 511514-03-7
• MW: 343.4249
• Purity: 99.12% (May vary between batches)
• Formula: C₂₁H₂₁N₅
• SMILES: CC1=CC(C)(C)N=C(NC2=NC3=C(C=CC=C3)C(=N2)C2=CC=CC=C2)N1
• Target: Adrenergic Receptor,Others,cAMP
• Solubility: DMSO:45 mg/mL (131.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM)

Bioactivity

• In Vitro:
  0990CL (at a concentration of 30 μM with a 30-minute pre-treatment) exhibits preferential binding to Gαi1 compared to Gαq. It displays selectivity towards Gαi and Gαq, resulting in a maximum reduction of endpoint fluorescence by 38±8% and 10%, respectively. Treatment with 0990CL (100 nM to 1 μM , 24 h) restores α2AR/Gαi-mediated cAMP levels induced by Fsk and UK14304 in HEK293 GloSensor cells. At a dosage of 100 nM, it reinstates 31% of the reduced cAMP levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

heterotrimeric G-protein complex, Gαi subunit, cAMP, 0990CL

Compound Identifiers

PubChem CID

950615