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Cleaved Caspase Antibodies
Detect activated caspase fragments including cleaved Caspase-3, -7, -8 and -9 for apoptosis pathway research.
BrowseCleaved / Neo-Epitope Antibodies
Detect proteolytically processed proteins with Biorbyt antibodies targeting cleaved fragments, cleavage-dependent epitopes and newly exposed protein termini.
Explore cleavage-specific antibodies for apoptosis, pyroptosis, Notch signalling, autophagy, extracellular matrix remodelling and other protease-regulated pathways.
Browse Cleaved & Neo-Epitope Antibodies
Start with the cleavage-dependent target or pathway you need to investigate.
Cleaved PARP Antibodies
Study caspase-dependent PARP processing using antibodies that recognise cleaved PARP / PARP1 forms.
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Cleaved Notch Antibodies
Detect proteolytically processed Notch receptors, including cleavage-specific Notch1, Notch2 and Notch4 targets.
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Cleaved GSDMD Antibodies
Study pyroptotic processing with antibodies targeting cleaved N-terminal or C-terminal Gasdermin D fragments.
BrowseAdditional Cleavage-Specific Antibodies
Explore additional proteolytically processed targets across cell death, autophagy, extracellular matrix remodelling and protease biology.
Cleaved Lamin A
Nuclear protein cleavage and apoptosis research
Cleaved LC3
Proteolytic processing in autophagy-related research
Cleaved Collagen
ECM cleavage and collagen fragment detection
Cleaved Cathepsins
Protease maturation and processed cathepsin forms
Cleaved Factor X
Proteolytic processing in coagulation research
Cleaved Integrins
Cleavage-dependent receptor fragment detection
Featured Cleaved & Neo-Epitope Antibodies
Compare representative Biorbyt cleavage-specific antibodies across apoptosis, pyroptosis, Notch signalling, autophagy and extracellular matrix remodelling.
| Focus | Featured Antibody | Cleavage / Fragment | Tested Applications | Reactivity | SKU |
|---|---|---|---|---|---|
| Apoptosis | Caspase 3 (Cleaved-Asp175) Antibody | Cleaved-Asp175 | IHC, WB | Human, Mouse, Rat | orb126608 |
| Apoptosis / DNA Damage | Cleaved PARP Recombinant Rabbit Monoclonal Antibody | Cleaved PARP | FC, ICC, IF, IHC-Fr, IHC-P, WB | Human, Mouse, Rat | orb704341 |
| Notch Signalling | Cleaved-Notch 2 (D1733) Polyclonal Antibody | D1733 | IF, IHC-P, WB | Human, Mouse, Rat | orb1416116 |
| Pyroptosis | Cleaved N-terminal GSDMD Rabbit Monoclonal Antibody | N-terminal fragment | WB | Human | orb3234870 |
| Autophagy | Cleaved LC3 Rabbit Polyclonal Antibody | Cleaved LC3 | ELISA, IHC, WB | Mouse, Rat | orb628392 |
| ECM Remodelling | Cleaved-COL1A2 (G1102) Rabbit pAb Antibody | G1102 | ELISA, WB | Human, Mouse, Rat | orb763909 |
Cleaved Antibody vs. Neo-Epitope Antibody
Proteolytic cleavage generates defined protein fragments and can create a new N- or C-terminus. Cleavage-specific antibodies are used to distinguish processed protein states from the full-length target. A true neo-epitope antibody specifically recognises the newly generated cleavage boundary, whereas some cleaved antibodies recognise a processed fragment more broadly.
When strict cleavage-site specificity is required, review the product's immunogen, epitope or specificity information, expected fragment and validation data before selection.
How to Choose a Cleavage-Specific Antibody
Selection should be based on the exact protein fragment and cleavage event you need to measure, not only on the parent protein name.
1
Identify the cleavage site or fragment
Check the cleavage residue and fragment designation, such as Cleaved-Asp175, p17, p20, N-terminal or C-terminal. Different cleavage products can represent different biological states.
2
Confirm cleavage-state specificity
Review the immunogen and specificity information to determine whether the antibody recognises a cleavage-generated neo-terminus, a defined cleavage site or a broader cleaved fragment.
3
Match application and fragment size
Confirm validation for your intended application and species. For Western blotting, compare the expected molecular weight of the cleaved fragment with the full-length protein.
4
Use appropriate cleavage controls
Where possible, pair the cleavage-specific antibody with a total-target antibody and include positive and negative cleavage controls to distinguish proteolytic processing from changes in total protein.
Need help selecting a cleavage-specific antibody?
Our scientific support team can help compare cleavage sites, fragments, expected molecular weights, species reactivity and available validation data.