Potassium oxonate

SKU: orb1301366

Description

Potassium oxonate is a uricase inhibitor used to establish experimental hyperuricemia models in vivo. It also suppresses the phosphorylation of 5-fluorouracil (5-FU) to its active metabolite, making it a relevant tool in oncology and metabolic disorder research.

Key Properties

• CAS Number: 2207-75-2
• MW: 195.17
• Purity: 99.86% (May vary between batches)
• Formula: C₄H₂KN₃O₄
• SMILES: [K+].[O-]C(=O)c1nc(=O)[nH]c(=O)[nH]1
• Target: Others
• Solubility: H2O:9.09 mg/mL (46.57 mM)

Bioactivity

• In Vivo:
  Potassium oxonate is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil, that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats.Formulations containing Potassium oxonate have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Oxonic Acid, Oxonic Acid (potassium salt), uricase, Potassium azaorotate, Potassium otastat, Potassium oxonate

Compound Identifiers

PubChem CID

2723920