Potassium iodide

SKU: orb2276873

Description

Potassium iodide is a small molecule used in research to study thyroid function and radioprotection. It is applied in both in vivo and in vitro models to investigate its mechanism in blocking radioactive iodine uptake and managing thyroid hormone synthesis.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 7681-11-0
• MW: 166.01
• Formula: IK
• SMILES: [K+].[I-]
• Target: Tyrosinase
• Solubility: H2O:30 mg/mL (180.71 mM);DMSO:31 mg/mL (186.74 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Potassium Iodide decreases Schiff's bases (SB) concentration in liver and lung homogenates afte the administration of PTU but, unexpectedly the level of SB increases in kidney homogenates of Wistar rats.
• In Vitro:
  Iodine induces abnormal morphologic Changes of cells, inhibited cell proliferation, and increases apoptosis rate in rat aorta endothelial cells. Iodine also reduce the activity of SOD, GSH-Px, and concentration of GSH and increase the concentration of MDA and protein carbonyl in a dose-dependent manner. Excess iodine decrease the activity of eNOS and increase the activity of iNOS an the expression of ICAM-1 and VCAM-1 in culture medium. Excess iodine exposure increases oxidative stress, causes damage of vascular endothelial cells, and altere the expression of adhesion factors an the activity of NOS. Potassium iodide increases avidity of some immune reactions including C-mediated cell lysis mediated by altered access of C-binding receptors. Potassium iodide (≥50 mM) increases lipid peroxidation in concentration dependent manner. Potassium iodide (25 mM) reduces Fenton reaction-induced lipid peroxidation. Potassium iodide is able to eliminate E faecalis from bovine root dentin when used with a 15 minute contact time.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Disclaimer: For research use only

Alternative Names

Tyrosinase, Potassium iodide

Compound Identifiers

PubChem CID

4875