Ponalrestat

SKU: orb1306741

Description

Ponalrestat is a selective aldose reductase inhibitor used in research to investigate diabetic complications. It is applied in both in vitro enzyme assays and in vivo animal models to study pathways involving neuropathy, retinopathy, and nephropathy.

Research Area

Metabolism Research

Key Properties

• CAS Number: 72702-95-5
• MW: 391.19
• Purity: 98.05% (May vary between batches)
• Formula: C₁₇H₁₂BrFN₂O₃
• SMILES: OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ccccc12
• Target: Reductase
• Solubility: DMSO:45 mg/mL (115.03 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.11 mM)

Bioactivity

• Target IC50:
  ALR1:60 μM (Ki)|ALR2:7.7 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ponalrestat, sorbitol, inhibit, noncompetitive, orally, Inhibitor, ICI 128436, ICI128436, ICI-128436, glucose, ALR1, ALR, ALR2, Aldose Reductase, Aldose reductase, AKR1B1, conversion

Compound Identifiers

PubChem CID

5278