PLX647

SKU: orb1706234

Description

PLX647 is a potent and selective small molecule inhibitor targeting the FMS (CSF1R) and KIT receptor tyrosine kinases, with IC50 values of 28 nM and 16 nM, respectively. It is utilized in preclinical research to investigate the roles of these kinases in oncology, inflammatory diseases, and neurobiology through both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 873786-09-5
• MW: 382.38
• Purity: 99.38%
• Formula: C₂₁H₁₇F₃N₄
• SMILES: FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncccc34)cn2)cc1
• Target: c-Kit,c-Fms
• Solubility: DMSO:31 mg/mL (81.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.23 mM)

Bioactivity

• Target IC50:
  c-Kit:16 nM|FMS:28nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-Kit, cKit, colony stimulating factor 1 receptor, CD117, c-Fms, cFms, cells, CSF1R, CSF-1 receptor, CSF-1R, differentiation, BCR-FMS, BCR-KIT, bone, PLX 647, PLX-647, PLX647, osteoclast, inhibit, Inhibitor, proliferation, SCFR

Compound Identifiers

PubChem CID

11545419