PLAUR antibody

• Catalog Number: orb154129
• Category: Antibodies
• Description: Rabbit polyclonal antibody to PLAUR. Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 4565 kDa, highly glycosylated, GPIanchored membrane protein. It contains three homologous domains (D1D3) of which the Nterminal one (D1) represents the uPAbinding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG
• Immunogen: Recombinant fusion protein of human PLAUR(NP_002650.1).
• Dilution range: WB: 1:500-2000
• Conjugation: Unconjugated
• MW: 36-72kDa
• UniProt ID: Q03405
• Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Buffer/Preservatives: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Alternative names: anti D87 antibody, anti UPAR antibody, anti URKR a
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of extracts of various cells using PLAUR antibody