Pirmenol

SKU: orb1220320

Description

Pirmenol is a new antiarrhythmic drug.(In Vitro):Pirmenol (1 μM) hydrochloride inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells.Pirmenol (5 μM) hydrochloride depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes.Pirmenol (1 μM) hydrochloride prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers.(In Vivo):Pirmenol (2.5 and 5 mg/kg, p.o.) hydrochloride is effective against the arrhythmias in conscious, coronary artery ligated dogs.Pirmenol (rats) hydrochloride shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.).Pirmenol (mice) hydrochloride shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.).

Key Properties

• CAS Number: 68252-19-7
• MW: 338.49
• Purity: >98% (HPLC)
• Formula: C₂₂H₃₀N₂O
• SMILES: C[C@H]1CCC[C@@H](C)N1CCCC(O)(c1ccccc1)c1ccccn1
• Target: Others

Bioactivity

• In Vivo:
  Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs. Pirmenol (rats) shows LD50s of 359.9 mg/kg (p. o), 23.6 mg/kg (i. v.). Pirmenol (mice) shows LD50s of 215.5 mg/kg (p. o), 20.8 mg/kg (i. v.). Animal model: Conscious, coronary artery ligated dogs. Dosage: Oral administration (p.o.). Administration: 2.5 and 5 mg/kg. Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
• In Vitro:
  Pirmenol (1 μM) inhibits the IK. ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells. Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes. Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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