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PIG3 Protein, Human, Recombinant (His)
Catalog Number: orb1958085
| Catalog Number | orb1958085 |
|---|---|
| Category | Proteins |
| Description | Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3. |
| Tag | N-His |
| Purity | 98.00% |
| MW | 37.8 kDa (predicted); 37.5 kDa (reducing conditions) |
| UniProt ID | Q53FA7 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3. |
| Expression Region | A DNA sequence encoding the human TP53I3 (NP_004872.2) (Met1-Gln332) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: His |
| Storage | -20°C |
| Note | For research use only |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expiration Date | 6 months from date of receipt. |
