Phospho-LRRK2 (Ser395) Antibody

• Catalog Number: orb1730696
• Category: Antibodies
• Description: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ICC, WB
• Reactivity: Human, Mouse
• Isotype: Rabbit IgG
• Immunogen: A synthesized peptide derived from human Phospho-LRRK2 (S935)
• Dilution range: WB: 1/500-1/1000; ICC: 1/50-1/200
• Conjugation: Unconjugated
• MW: Calculated MW: 286 kDa; Observed MW: 286 kDa
• Entrez: 120892
• UniProt ID: Q5S007
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Alternative names: AURA17; Dardarin antibody; ; Leucine rich repeat k
• Note: For research use only
• Expiration Date: 12 months from date of receipt.