Phospho-LAT (Tyr200) Antibody

• Catalog Number: orb1733086
• Category: Antibodies
• Description: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
• Species/Host: Rabbit
• Clonality: Monoclonal
• Tested applications: WB
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr200 of human LAT
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000
• Conjugation: Unconjugated
• MW: Calculated MW: 28 kDa; Observed MW: 36-38 kDa
• Entrez: 27040
• UniProt ID: O43561
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin
• Alternative names: LAT; Linker for activation of T-cells family membe
• Note: For research use only
• Expiration Date: 12 months from date of receipt.