Phospho-4E BP1 (Thr70) Antibody

• Catalog Number: orb1730626
• Category: Antibodies
• Description: Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: IHC
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: Synthetic peptide of human EIF4EBP1
• Dilution range: IHC: 1/50-1/100
• Conjugation: Unconjugated
• Entrez: 1978
• UniProt ID: Q13541
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: EIF4EBP1; Eukaryotic translation initiation factor
• Note: For research use only
• Expiration Date: 12 months from date of receipt.