Phenylephrine

SKU: orb1307589

Description

Phenylephrine is a selective α1-adrenergic receptor agonist, demonstrating highest affinity for the α1D subtype. It is widely used in research to study vascular tone and blood pressure regulation in both in vitro receptor binding assays and in vivo physiological models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59-42-7
• MW: 167.21
• Purity: 99.92% (May vary between batches)
• Formula: C₉H₁₃NO₂
• SMILES: CNC[C@H](O)c1cccc(O)c1
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (29.9 mM);DMSO:100 mg/mL (598.05 mM);H2O:5 mg/mL (29.9 mM)

Bioactivity

• Target IC50:
  α1D-adrenoceptor:5.86 (pKi)|α1A-adrenoceptor:4.70 (pKi)|α1B-adrenoceptor:4.87 (pKi)
• In Vivo:
  Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes .
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• In Vitro:
  Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L-Phenylephrine, (R)-(-)-Phenylephrine, Adrenergic Receptor, AdrenergicReceptor, α1A-adrenergic receptor, α1D-adrenergic receptor, α1B-adrenergic receptor

Compound Identifiers

PubChem CID

6041