PF-915275

• Catalog Number: orb1307890
• Category: Small Molecules
• Description: PF-915275
• CAS Number: 857290-04-1
• Purity: 98.62%
• MW: 350.39
• SMILES: S(NC=1N=C(N)C=CC1)(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C#N)C=C3
• Formula: C₁₈H₁₄N₄O₂S
• Biological Activity: PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.