PF-670462

SKU: orb1304568

Description

PF-670462 is a highly potent and selective inhibitor of CK1ε, exhibiting an IC50 of 7.7 nM and over 30-fold selectivity against a broad kinase panel. This compound is a valuable chemical probe for studying circadian rhythms, Wnt/β-catenin signaling, and cancer biology in both cellular and animal models.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 950912-80-8
• MW: 410.32
• Purity: 99.72%
• Formula: C₁₉H₂₂Cl₂FN₅
• SMILES: Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
• Target: Casein Kinase
• Solubility: DMSO:55 mg/mL (134.04 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.09 mM)

Bioactivity

• Target IC50:
  CK1ε:7.7 ± 2.2 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Casein Kinase, CaseinKinase, CK1ε, PF-670462, PF670462, PF 670462

Compound Identifiers

PubChem CID

51049607