PF-670462 dihydrochloride

SKU: orb1304568

Description

PF-670462 is a highly potent and selective inhibitor of CK1ε, exhibiting an IC50 of 7.7 nM and over 30-fold selectivity against a broad kinase panel. This compound is a valuable chemical probe for studying circadian rhythms, Wnt/β-catenin signaling, and cancer biology in both cellular and animal models.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 950912-80-8
• MW: 337.4
• Purity: >98%
• Formula: C₁₉H₂₂Cl₂FN₅
• SMILES: Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
• Target: Kinase
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

• Target IC50:
  CK1ε:7.7 ± 2.2 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Casein Kinase, CaseinKinase, CK1ε, PF-670462, PF670462, PF 670462

Compound Identifiers

PubChem CID

51049607